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Thursday, May 10, 2018

The First person who got rid of from HIV

Timothy Ray Brown is the only  human ever cured of HIV. He had the virus for 11 years before developing leukemia. When he was given a bone marrow transplant, the HIV virus disappeared. His blood has been studies for years but there’s still no definitive answer as to why he recovered.

Timothy Ray Brown
Timothy Ray Brown-tech columnist

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Timothy Ray Brown (1966) is an American boy considered to be the first person cured of HIV/AIDS.Brown was diagnosed with HIV in 1995 while studying in Berlin, Germany.they give him the nickname The Berlin Patient.



In 2007, Brown, who was dettect as HIV positive, underwent a treatment known as hematopoietic stem cell transplantation to treat leukemia disease.From  matching sixty donors,berlin doctors selected a [CCR5]-Δ32 homozygous individual with two genetic copies of a rare variant of a cell surface receptor. This genetic trait confers resistance to HIV infection by blocking attachment of HIV to the cell. Roughly 10% of people of European ancestry have this inherited mutation, but it is rarer in other populations.The transplant was repeated a year later after a relapse. Over three years after the initial transplant and despite discontinuing antiretroviral therapy, researchers  detect there is no HIV in the transplant recipient's blood or in various biopsies. the Levels of HIV-specific antibodies have also decreased, leading to speculation that the patient may have been functionally cured of HIV. However, scientists emphasise that this is an unusual case that doesn't happen all time. Potentially fatal transplant complications mean that the procedure could not be performed in others with HIV, even if sufficient numbers of suitable donors were found.

However There is now doubt  that Timothy Brown's apparent cure was due to the unusual nature of the stem cells that he received. As allready mentioned, he suffered graft-versus-host disease. Six more people seem (as of 2017) to have been freed of HIV after getting treament for graft-versus-host disease, and only one of them had received CCR5 mutant stem cells. So it appears that when someone gets graft-versus-host disease the transplanted cells may kill off all the host's HIV-infected immune cells.
This is the great invetion of medical science against HIV virus.

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